The intake of food prior to dose administration slowed absorption (2.8-fold, RSE 13%) and increased relative bioavailability of E7820 by 36% (RSE 14%), although the effect on C Final population parameter estimates of basic PK parameters obtained with the PopPK method were (RSE): clearance, 6.24 L/h (7.1%), volume of distribution, 66.0 L (8.5%), mean transit time to the absorption compartment, 0.638 h (6.5%). A one compartment model with linear elimination from the central compartment was shown to give adequate fit, while absorption was described using a turnover model. E7820 was administered daily for 28 days, followed by a washout period of 7 days prior to the start of subsequent cycles. Data were obtained from a phase I dose escalation study in patients with malignant solid tumors or lymphomas. Both a non-linear mixed effects modeling analysis and a non-compartmental analysis (NCA) were performed and results were compared.
The aim of this study was to assess the population pharmacokinetics (PopPK) of the novel oral anti-cancer agent E7820.
Keizer, Ron Zamacona, Miren Jansen, Mendel Critchley, David Wanders, Jantien Beijnen, Jos Schellens, Jan Huitema, Alwin Application of population pharmacokinetic modeling in early clinical development of the anticancer agent E7820 Application of population pharmacokinetic modeling in early clinical development of the.
0 kommentar(er)
